Conveniently located on the Chicago Transit Authority's (CTA) Blue Line, a stay in Wicker Park does not require the rental of a car. Blue Line elevated / subway trains running from Chicago's O'Hare International Airport to the Loop, pass through the center of the Wicker Park neighborhood. In fact, Wicker Park is an ideal base for exploring all of Chicago's sights. All major attractions are only a short train, bus, or taxi ride away.
For more information on Chicago transportation, click on the logo above. The CTA website has an invaluable "Trip Planner" that allows you to calculate the time and cost of using CTA to explore the city.